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Thermo Fisher Scientific

AN 9799 - The Use of FT-Raman Spectroscopy and Chemometric Procedures in the Analysis of Pharmaceuticals


The FT-Raman technique has many benefits in the analytical laboratory, including speed, easy sample preparation and spectral information that is interpreted in the same way as FT-IR spectra. Functional groups such as carbon double bonds produce strong FT-Raman vibrations, whereas functional groups with strong dipoles, such as water, are often weak in FT-Raman spectra. Therefore, aqueous solutions or samples in glass bottles can be measured directly. In addition, the active ingredients present in pharmaceutical tablets often show a very strong FT-Raman spectra while their excipients have much weaker vibrations.