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Thermo Fisher Scientific

TN 1558 - Introduction to Method Transfer Between Raman Spectrometers

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This technical note provides an overview of method transfer between Raman spectrometers, focusing on how chemometric models can be successfully transferred between instruments while maintaining accuracy.

Description: 

This technical note provides an overview of method transfer between Raman spectrometers, focusing on how chemometric models can be successfully transferred between instruments while maintaining accuracy. It explains key factors affecting transfer—such as spectral shifts, intensity variations, and measurement conditions—and compares common approaches including direct transfer, global methods, and correction/standardization techniques. The document highlights practical considerations and optimization strategies to improve method robustness and ensure reliable quantitative results across multiple instruments.

Note: The content is broadly applicable to Raman instruments across product lines; however, the examples shown utilize the DXR3 SmartRaman+ system and ASA sampling accessory.

The multi-vial holders  shown are illustrative only and are not provided by Thermo Fisher Scientific.

Environment:

  • DXR2, DXR3, SmartRaman
  • DXR2xi, DXR3xi
  • DXR3 Flex, iXR
  • DXR3 SmartRaman+