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Thermo Fisher Scientific

ISN 0006 - Quantification of the Active Ingredient in a Pharmaceutical Topical Gel Formulation


This report demonstrates that Fourier transform near-infrared (FT-NIR) spectroscopy can be used for the quantitative characterization of an active ingredient in a translucent gel formulation. Gels were prepared with 0%, 1%, 2%, 4%, 6% and 8% ketoprofen. These preparations were placed in disposable vialsand analyzed with the Antaris™ FT-NIR analyzer in the transmission module. The results demonstrate that FT-NIR is agood alternative to other analyses, which are time-consuming, for these formulations.


  • FT-NIR
  • Antaris