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Thermo Fisher Scientific

Troubleshooting DFU Mode on ASX-560 Autosampler

Originally submitted by kendall.norwood@thermofisher.com on 6/20/2025 7:04:25 PM UTC

Issue

The ASX-560 Autosampler is not communicating with the computer and is showing up as DFU instead of USB to Serial.

Environment

  • ASX-560 Autosampler

Resolution

  1. Verify that the ASX-560 is properly connected to the computer.
  2. Open the device manager on the XE4 computer.
  3. Locate the ASX-560 under the devices list.
  4. If it is listed as DFU, proceed with the following steps:
    1. Unplug the USB cable from the ASX-560.
    2. Power cycle the ASX-560 by turning it off and then on again.
    3. Reconnect the USB cable to the ASX-560.
    4. If the issue persists, the firmware needs to be updated see How to Resolve Firmware Issues on Cetac 560.