Skip to main content
Thermo Fisher Scientific

90242 - iCAP - Technical Guide


The United States Pharmacopeia (USP) is in the process of implementing new guidelines for the determination of elemental impurities in drug-related products. The current guidelines are described in the USP General Chapter <231>, titled “Heavy Metals.” This chapter outlines a method for determining metal impurities in solutions based on a metal sulfi de precipitation reaction. The reaction produces a color change which is compared to a prepared lead standard. This method has been used for years; however, it suffers from a number of drawbacks related to sensitivity, selectivity, stability and reproducibility.



  • Was this article helpful?