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Thermo Fisher Scientific

ISN 0025 - Use of Diffuse Reflectance Fourier Transform Near-Infrared Spectroscopy to Confirm Blend Uniformity


Diffuse reflectance Fourier transform near-infrared (FT-NIR) spectroscopy was investigated as a tool to monitor the integrity of production blending processes. Laboratory blends were used to produce calibration samples for two different products. The calibration models derived from these blends were then used to predict the contents of real production samples for the respective products. The results of this study demonstrate that FT-NIR is a good approach for in-process confirmation of blending. The excellent sample interrogation provided by FT-NIR was deemed critical for this application.