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Thermo Fisher Scientific

ISN 0026 - Investigation of Different Sampling Techniques for the Analysis of Capsule Contents by Fourier Transform Near-Infrared Spectroscopy

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Description: 

Fourier transform near-infrared (FT-NIR) spectroscopy was investigated as a means for qualitative and quantitative analysis of conventional hard gelatin capsules. Analyses were performed with minimal or no sample preparation. Two sampling techniques were explored: intact whole capsule reflectance and reflectance analysis of the capsule contents removed from the shell. The viability of each sampling option was investigated and the effectiveness of FT-NIR for capsule analysis was assessed.