Skip to main content
Thermo Fisher Scientific

ISN 0026 - Investigation of Different Sampling Techniques for the Analysis of Capsule Contents by Fourier Transform Near-Infrared Spectroscopy


Fourier transform near-infrared (FT-NIR) spectroscopy was investigated as a means for qualitative and quantitative analysis of conventional hard gelatin capsules. Analyses were performed with minimal or no sample preparation. Two sampling techniques were explored: intact whole capsule reflectance and reflectance analysis of the capsule contents removed from the shell. The viability of each sampling option was investigated and the effectiveness of FT-NIR for capsule analysis was assessed.