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Thermo Fisher Scientific

Liquid leaks


Integrion experiencing liquid leaks.


  • Integrion
  • Chromeleon


Below are various potential issues and possible solutions:




Fitting or broken liquid line

Tighten the fitting, or replace the tubing and fittings as required

Bottom seal wash tube

(when tubing is not installed)

1. Liquid dripping from the bottom seal wash tube indicates a defective pump seal.

2. Replace the pump seals:

a. Main seal (P/N 075768)

b. Seal wash seal (P/N 063382)

c. O-ring (P/N 040695)


Check valve 

1. Follow the instructions below to tighten the check valves:

a. Turn off the pump.

b. Loosen the check valve enough to allow it to turn freely.

c. Tighten the check valve fingertight, and then tighten it one-quarter turn using a 1/2 inch wrench. 

d. If the check valve continues to leak, tighten it an additional one-quarter turn using a 1/2 inch wrench.

2. If the leaking check valve is securely tightened but allows leaks despite this, the valve is defective. Replace both check valves:

a. Inlet check valve assembly (P/N 045722

b. Outlet check valve assembly (P/N 045721)

Dionex EGC

Replace the Dionex EGC. 

Priming valve knob

1. If the knob leaks when open, close the knob completely and then open it one-half to three-quarters turn. If the leak still occurs, replace the seal.

2. If the knob leaks when closed, replace the seal.

3. If the leak still occurs, either the pump head or the knob is damaged and should be replaced. 

High-pressure valve

1. Verify that the liquid line connections to the valve are tight. Replace any damaged fittings.

2. If the leak is from behind the valve stator, the rotor seal may be scratched. Rebuild the valve:

a. 4-port Valve Rebuild Kit (P/N 074698)

b. 6-port Valve Rebuild Kit (P/N 075973

c. 10-port Valve Rebuild Kit (P/N 079054)

Detector cell

1. Check the waste lines for blockage; trapped particles can plug the lines and cause a restriction and/or leak. If necessary, clear the waste lines by reversing the direction of flow.

2. Verify that the plumbing downstream from the cell is clear; a blockage may over pressurize the cell and cause it to leak.


1. Verify that the plumbing downstream from the suppressor is clear; a blockage may over pressurize the suppressor and cause it to leak. 

2. If the suppressor continues to leak when operated within the proper backpressure range, it must be replaced.

3. Refer to the suppressor manual for operating pressure guidelines and for additional troubleshooting information. 



NOTE: After eliminating the source of a leak, always dry the drip tray and the leak sensor thoroughly. If the leak sensor is not dry, it will remain activated and will continue to report a leak to the Chromeleon audit trail.

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