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Thermo Fisher Scientific

Low or Decreasing System Backpressure

Issue

How can I troubleshoot an Integrion system when the unit may be experiencing low or decreasing system backpressure?

Environment

Integrion Models:

  • 22153-60301
  • 22153-60302
  • 22153-60303
  • 22153-60304
  • 22153-60305
  • 22153-60306

Resolution

The following table summarizes possible causes why product may have low or decreasing system backpressure and troubleshooting tips to resolve the issue(s):

Eluent supply depleted
  • Check the eluent reservoir and refill it if needed. Prime the pump before resuming operation. 
  • Air in eluent line Check the eluent line for air bubbles.
  • If air is trapped in the line, replace the end-line filter (P/N 045987).
  • Verify that the end of the line extends to the bottom of the reservoir and the filter is submerged in eluent. Prime the pump.
Eluent insufficiently degassed
  • If the optional eluent degas vacuum pump is installed, verify that the pump is turned on.
  • The vacuum pump can be controlled from the pump ePanel in Chromeleon or the mobile app Pump page.
Loose fitting
  • Check tubing connections throughout the system (including the check valves, injection valves, and columns) and tighten or replace fittings as needed.
  • Pump priming valve open
  • To close the valve, turn the knob clockwise until closed. Tighten no more than fingertight.
Column temperature too high
  • Check the temperature setpoint of the column compartment.
  • If the compartment is set at the correct temperature and the reading is stable, use an external temperature probe to measure the temperature.
  • If the reading does not match the temperature reported by the system, the column compartment heater may need to be replaced. Contact Technical Support for Dionex products for assistance.
Compartment temperature too high
  • Check the temperature of the detector compartment.
  • If the compartment is set at the correct temperature and the reading is stable, use an external temperature probe to measure the temperature.
  • If the reading does not match the temperature reported by the system, the compartment heater many need to be replaced.
Defective pump check valve
  • Replace the check valves
Internal Dionex EGC leak (from membrane barrier)
  • Leakage from the membrane barrier may trip the pump low pressure limit and shut down the pump.
  • If all other causes of the low system pressure have been eliminated, replace the Dionex EGC.

 

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