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Thermo Fisher Scientific

How to Replace the Pump Head


  • The wetted surface is damaged, resulting in internal leaks compromising pump performance; or
  • The pressure sensor is faulty.


Vanquish HPLC and UHPLC systems


Replace the pump head by following the steps in the video below.

Required parts:
  • New pump head
  • Spacing tool
  • Size 6 hexagonal wrench
  • ¼” wrench
Preparation steps:
  1. Flush the pump head with an appropriate solvent using the purge function
  2. Turn off the pump flow and wait until the system pressure is zero


The Vanquish HPLC and UHPLC systems offer uncompromised performance, robustness, and ease of use. A key element of its user-friendly functionality is the accessibility of the system for simple maintenance and replacement procedures. These videos provide step-by-step instructions on how to perform these procedures and keep your Vanquish HPLC and UHPLC systems operating smoothly. To access these procedures from your instrument, without the need for an external internet connection, consider adding the Vanquish User Interface to your system.