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Thermo Fisher Scientific

How to Replace the Sample Loop, Needle Unit and Needle Seat


  • Clogged or damaged needle;
  • Clogged or damaged sample loop; or
  • Worn needle seat.


Vanquish HPLC and UHPLC systems


Replace the needle or sample loop if either one becomes clogged or damaged. The needle seat should be replaced whenever it is worn out.

Required parts:

  • New sample loop
  • New needle unit
  • New needle seat
  • Screwdriver Torx T10


The Vanquish HPLC and UHPLC systems offer uncompromised performance, robustness, and ease of use. A key element of its user-friendly functionality is the accessibility of the system for simple maintenance and replacement procedures. These videos provide step-by-step instructions on how to perform these procedures and keep your Vanquish HPLC and UHPLC systems operating smoothly. To access these procedures from your instrument, without the need for an external internet connection, consider adding the Vanquish User Interface to your system.


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