Pump Problems

Issue

How to troubleshoot if the unit is experiencing peak pump problems?

Environment

Vanquish Flex Binary UHPLC System
Vanquish Flex Quaternary UHPLC System

Resolution

POSSIBLE CAUSE	REMEDIAL ACTION
Piston seals in pump leaking	Replace the seals (refer to Pump Operating Manual).
Air trapped in pump head	Purge the pump (refer to Pump Operating Manual).
Baseline fluctuations	See "Periodic baseline fluctions" in Baseline on page 121.
Pump pulsation or flow fluctuations	See "Pressure pulsation or inconstant pressure" in Pressure on page 120.
Irreproducible gradient	Change the gradient. Check the solvent line filters for permeability. Replace the filter frits if necessary. (refer to Pump Operating Manual).

For additional troubleshooting help try downloading the Thermo Scientific HPLC Troubleshooting Guide App. The app is an extensive tool to effectively diagnose various potential issues with HPLC analysis.

Thermo Scientific HPLC Troubleshooting Guide App (Apple App Store)

Thermo Scientific HPLC Troubleshooting Guide App (Google Play)